Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats
Figure 1
Histopathology of liver sections for groups 1–6: hematoxylin and eosin stain of liver tissue. (a) Control group showed normal hepatic architecture (H&E ×100). (b) Ethinylestradiol plus chlorpromazine treated group showed numerous apoptotic figures (pyknosis; one arrow and karyolysis; two arrows), intracellular bile pigments three arrows (H&E ×200). (c) Ethinylestradiol plus chlorpromazine treated group showed main bile duct obstruction, dilatation, and ductular proliferation (H&E ×100). (d) Ursodeoxycholic acid group showed ground glass cytoplasmic appearance of hepatocytes with congested dilated blood sinusoids (H&E ×200). (e) Fenofibrate group showed mild ground glass appearance of hepatocytes, proliferated bile ductules (one arrow) (H&E ×200). (f) Bezafibrate group showed proliferated bile ductules, congested central veins, and minimal mononuclear cellular infiltration (H&E ×200). (g) Gemfibrozil group showed mild hepatitic changes, portal tracts with mononuclear cellular infiltration, and proliferated bile ductules (H&E ×200).