Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats
Figure 2
Histopathology of liver sections for groups 7–10: hematoxylin and eosin stain of liver tissue (H&E ×200). (a) Animals treated with GW6471 before fenofibrate and EE & CPZ showed highly eosinophilic cells (one arrow) and necrotic cells (two arrows) with dense mononuclear cellular infiltrations and hypertrophied kupffer cells. (b) Rats treated with GW6471 before fenofibrate and EE & CPZ showed dilated bile duct with no proliferation (H&E ×100). (c) Portal tract in rats treated with GW6471, bezafibrate, EE, and CPZ showed dense mononuclear cellular infiltration and moderate hepatitis changes (H&E ×100). (d) Animals treated with GW6471, gemfibrozil, EE, and CPZ showed dilated engorged central vein and blood sinusoid, mononuclear cellular infiltration, and vacuolar degeneration of liver cells.
