Effects of Three Different Fibrates on Intrahepatic Cholestasis Experimentally Induced in Rats

Table 1

Effect of ursodeoxycholic acid, fenofibrate, bezafibrate, and gemfibrozil on serums ALP, GGT, ALT, AST, TBA, direct bilirubin, total bilirubin, IL-1𝛽, TNF𝛼, and hepatic MDA levels in EE and CPZ treated rats.

Parameter	Control	EE + CPZ	UDCA	Fenofibrate	Bezafibrate	Gemfibrozil
ALP U/L	𝟏𝟗𝟐.𝟗𝟗±22.9	𝟓𝟓𝟔.𝟓𝟗±69.5^∗	𝟐𝟗𝟒.𝟕𝟑±58.9^a	𝟐𝟔𝟎.𝟑±51.4^a	𝟐𝟖𝟗.𝟗±41.8^a	𝟐𝟓𝟏.𝟔𝟐±34.1^a
GGT U/L	𝟔.𝟐𝟔±2.8	𝟏𝟗.𝟗±5.4^∗	𝟗.𝟑𝟖±3.76^a	𝟖.𝟑±2.3^a	𝟗.𝟎𝟏±2.26^a	𝟓.𝟕±1.5^a
AST U/mL	𝟔𝟐.𝟑𝟒±8.3	𝟏𝟓𝟎.𝟔𝟗±15.6^∗	𝟗𝟕.𝟕±5.09^a	𝟏𝟐𝟓.𝟖±20.55^a	𝟗𝟖.𝟎𝟐±11.18^a	𝟗𝟓.𝟒±10.07^a
ALT U/mL	𝟒𝟐.𝟏𝟔±7.66	𝟖𝟓.𝟓±11.83^∗	𝟓𝟕.𝟑±5.5^a	𝟕𝟏.𝟕𝟕±13.4^a	𝟔𝟒.𝟑±11.5^a	𝟔𝟎.𝟓±12.3^a
TBA 𝜇mole/L	𝟏𝟒.𝟓±7.08	𝟖𝟏.𝟕𝟓±20.2^∗	𝟑𝟑.𝟓𝟔±1.45^a	𝟐𝟑.𝟑𝟖±6.24^a	𝟑𝟎.𝟒𝟓±1.46^a	𝟐𝟐.𝟔𝟔±3.16^a
Direct Bil. 𝜇mole/L	𝟎.𝟒𝟑𝟔±0.07	𝟐.𝟎𝟔𝟓±0.36^∗	𝟏.𝟏𝟖𝟐𝟔±0.304^a	𝟎.𝟗𝟕𝟓±0.324^a	𝟏.𝟎𝟖𝟔±0.33^a	𝟎.𝟗𝟑𝟐±0.333^a
T. Bil. μmole/L	𝟏.𝟒𝟕±0.39	𝟓.𝟒𝟐±1.39^∗	𝟐.𝟒𝟗𝟔±0.48^a	𝟐.𝟎𝟏𝟗𝟕±0.476^a	𝟐.𝟑𝟓𝟗±0.436^a	𝟏.𝟖𝟓±0.873^a
IL-1𝛽 pg/mL	𝟎.𝟏𝟎𝟒±0.02	𝟎.𝟐𝟕±0.059^∗	𝟎.𝟏𝟗𝟔±0.044^a	𝟎.𝟏𝟎𝟗±0.012^a	𝟎.𝟏𝟑±0.026^a	𝟎.𝟏𝟎𝟔±0.019^a
TNF𝛼 ng/mL	𝟎.𝟎𝟗𝟑±0.109	𝟎.𝟏𝟔𝟒𝟖±𝟎.𝟐𝟗^∗	𝟎.𝟏𝟏𝟓𝟖±0.223^a	𝟎.𝟎𝟗𝟗𝟕±0.105^a	𝟎.𝟎𝟗𝟑𝟗±0.05^a	𝟎.𝟏𝟎𝟐𝟔±0.06^a
MDA 𝜇mole/gm tissue	𝟐𝟎.𝟒𝟑𝟐±0.1	𝟕𝟓.𝟗𝟔±12.84^∗	𝟓𝟖.𝟎𝟏±20.45^a	𝟐𝟐.𝟕𝟗±6.455^a	𝟐𝟒.𝟑𝟒±9.3^a	𝟐𝟐.𝟗𝟐±5.5^a
Bile flow rate μL/min/Kg b·wt	𝟐𝟓.𝟔𝟗±5.4	𝟑.𝟖𝟔𝟕𝟓±2.3^∗	𝟏𝟐.𝟏𝟐±1.7^a	𝟏𝟒.𝟒𝟔𝟓±1.8^a	𝟏𝟖.𝟒𝟖±1.59^a	𝟏𝟑.𝟕𝟏𝟕𝟓±1.8^a

ALP: alkaline phosphatase; GGT: gamma glutamyl transpeptidase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TBA: total bile acids; Direct Bil: direct bilirubin; T. Bil.: total bilirubin; IL-1𝛽: interleukin-1beta; TNF𝛼: tumor necrosis factor alpha; MDA: malondialdehyde; EE: ethinylestradiol, CPZ: chlorpromazine; UDCA: ursodeoxycholic acid. Data are presented as mean ± SD. ∗Significantly different from control group 𝑃<0.05, asignificantly different from EE + CPZ group 𝑃<0.05.