Correlation between PPAR Gene Polymorphisms and Primary Nephrotic Syndrome in Children

Table 4

Stratified analysis of the PGC-1α (Gly482Ser) genotypes among PNS children.

Subjects	PGC-1α gene			𝜒^2/𝐹	𝑃 value
	GA	AA	GG
Gender (male/female)	46/13	21/10	11/7	2.388	0.303
Age (years)	3.60 (1.50–13.08)	3.00 (0.67–10.58)	4.40 (1.33–9.80)	3.058	0.217
BMI	16.84±0.29	17.47±0.36	16.98±0.54	0.874	0.420
sBP (kp)	14.18±0.17	14.36±0.29	14.49±0.34	0.384	0.682
dBP (kp)	9.15±0.13	9.14±0.18	9.19±0.32	0.014	0.986
ALB (g/L)	17.60 (11.20–37.00)	18.10 (12.80–26.30)	18.40 (11.30–27.60)	0.327	0.849
BUN (mmol/L)	4.10 (2.30–21.50)	3.50 (0.50–16.30)	3.85 (2.20–13.10)	3.363	0.186
Scr (μmol/L)	37.20 (18.30–67.80)	36.50 (23.00–207.60)	38.80 (25.30–69.70)	0.416	0.812
UA (mmol/L)	349.73±14.53	357.90±19.21	353.56±27.52	0.055	0.946
GFR (mL/(min·1.73 m^2))	139.62±4.11	136.34±7.52	135.69±7.27	0.140	0.870
TC (mmol/L)	9.60±0.36	10.12±0.42	10.42±0.89	1.164	0.559
TG (mmol/L)	2.60±0.16	3.46±0.30	2.77±0.35	3.766	0.026 *
HDL-c (mmol/L)	1.57±0.08	1.38±0.08	1.42±0.11	1.299	0.277
Fbg (g/L)	4.32±0.21	4.78±0.42	4.79±0.33	0.917	0.406
IgA (g/L)	1.03±0.06	1.02±0.08	1.10±0.11	0.218	0.804
IgG (g/L)	2.25 (1.36–7.95)	2.30 (1.36–4.79)	1.96 (1.43–7.51)	0.044	0.978
IgM (g/L)	1.73±0.09	1.75±0.12	1.55±0.12	0.603	0.549
C3 (g/L)	1.24±0.03	1.36±0.05	1.18±0.07	3.193	0.045*
C4 (g/L)	0.28 (0.10–1.13)	0.28 (0.10–0.49)	0.26 (0.13–0.49)	0.412	0.814
T (CD3+) (%)	69.85±1.25	64.62±2.44	72.93±2.13	4.755	0.093
T (CD4+) (%)	37.15±1.26	33.77±2.09	34.71±1.50	1.312	0.275
T (CD8+) (%)	27.73±0.88	25.19±1.59	32.00±1.86	4.469	0.014*
NK (%)	10.09±1.04	10.77±1.53	7.57±0.94	1.012	0.368
BC (%)	17.68±0.88	21.08±2.00	18.07±1.85	1.299	0.522
FBG (mmol/L)	4.82±0.08	4.99±0.13	4.85±0.12	0.733	0.483
FISN (mU/L)	2.37 (0.20–9.43)	1.92 (0.57–16.63)	2.13 (0.76–12.87)	0.180	0.914
FCP (nmol/L)	0.45 (0.18–1.24)	0.50 (0.22–1.95)	0.50 (0.24–1.15)	2.386	0.303
HOMA-IR	0.68±0.07	0.89±0.19	0.76±0.17	0.218	0.897
HOMA-islet	37.22 (−141.54–895.56)	38.47 (5.50–278.22)	28.78 (13.66–224.47)	0.192	0.908
ISI	−2.29 ± 0.14	−2.46 ± 0.18	−2.51 ± 0.19	0.468	0.628
24-h UP (mg/kg)	141.71 (11.25–1179.80)	125.88 (27.69–319.00)	176.52 (45.00–301.00)	1.064	0.587

^∗𝑃<0.05, ^∗∗𝑃<0.01.