PPAR Research / 2013 / Article / Fig 7

Research Article

Interactions between Human Liver Fatty Acid Binding Protein and Peroxisome Proliferator Activated Receptor Selective Drugs

Figure 7

(a) The conformational nuclear localisation signal formed in A-FABP upon binding of an activating ligand. The portal region of A-FABP is shown in ribbon representation in complex with an activator ligand troglitazone (red; PDB code: 2QM9.pdb) and in complex with a non-activator ligand, arachidonic acid (cyan; PDB code: 1ADL.pdb). The side chains of the NLS residues (Lys21, Arg30, Lys31) and cavity lid residue (Phe57) are shown in sticks representation. Below, sequence alignment of the NLS region of human A-FABP, with human I- and L-FABP. NLS residues are highlighted in bold on a grey background. (b) Putative mechanism for the transfer of ligands from FABPs to PPAR LBDs.

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