Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study

Table 3

PPARD, PPARG, and PPARGC1A polymorphisms and eGFR.

Polymorphism	Genotype	n	eGFR	𝛽^∗dom	P value	𝛽pa^∗∗	P value
PPARD A65G in exon 7 (Asn163Asn) (rs2076167)	A/A	2,012	74.3±14.8
	G/A	1,143	73.4±15.2	−0.607±0.422	0.151	0.130±1.153	0.911
	G/G	160	74.1±15.0
PPARD T-48444C in exon 3 (rs6902123)	T/T	3,187	73.9±14.9
	C/T	126	75.8±15.9	1.458±1.254	0.245	3.272±10.070	0.745
	C/C	2	77.7±17.4
PPARD T-842C in exon 3 (rs2267668)	T/T	2,118	74.4±14.7
	C/T	1,062	73.2±15.4	−0.826±0.436	0.058	−0.320±1.251	0.798
	C/C	135	73.9±13.8
PPARG C161T (His477His) (rs3856806)	C/C	2,369	74.2±15.0
	C/T	883	73.3±14.4	−0.517±0.495	0.296	1.727±1.810	0.340
	T/T	63	75.4±16.7
PPARG Pro12Ala (rs1801282)	C/C	3,113	74.1±14.9
	C/G	198	73.1±14.5	−1.303±1.003	0.194	−8.380±7.119	0.239
	G/G	4	64.5±18.3
PPARGC1A Thr394Thr (rs2970847)	C/C	2,033	74.0±14.9
	C/T	1,116	74.0±14.7	−0.004±0.420	0.993	−0.291±1.134	0.797
	T/T	166	73.8±16.7
PPARGC1A Gly482Ser (rs8192678)	G/G	950	73.8±15.1
	A/G	1,665	74.0±14.7	0.182±0.352	0.606	0.302±0.606	0.619
	A/A	700	74.3±15.3

eGFR: estimated glomerular filtration rate; data are shown in mean ± SD (standard deviation).
∗β coefficient based on linear regression model (dominant model) adjusted for age and sex; data are shown in mean ± SE (standard error).
∗∗β coefficient based on linear regression model (per allele model) adjusted for age and sex; data are shown in mean ± SE (standard error).