The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα

Figure 2

Atherosclerosis at the aortic sinus. Representative photographs of the oil-red-O-stained lesions ((a)–(d)), and after quantification (e), mice number in parentheses. Atherosclerosis was 23% lower in the DKO control mice (c) versus the ApoE-null (a), *𝑃<0.05. L-NAME increased the extent of the plaque by 23% in the ApoE-null mice, ((a), (b), and (e)), *𝑃<0.05, but had no effect in the DKO ((c), (d), and (e)), resulting in a 37% greater plaque area in the treated ApoE-null mice versus the treated DKO animals, **𝑃<0.005.

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