The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα
Figure 4
Aortic iNOS is induced by L-NAME in ApoE-null mice and correlates with atherosclerosis. Effects are expressed relative to the control ApoE-null mice. (a) iNOS expression by real-time PCR indicates a 4-fold excess in control ApoE-null versus DKO (*) and a tenfold difference after L-NAME (**), number of mice used in the experiment: 9 apoE-null control: 7 apoE-null L-NAME, 8 DKO control, and 8 DKO L-NAME. (b) eNOS is significantly increased by L-NAME in the DKO but not in the ApoE-null mice, animals in each group. (c) Significant positive correlation between the extent of the plaque and iNOS expression.
