Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse

Figure 2

Glucose tolerance test in male WT and Wfs1 mutant mice after 3-month VPA treatment (300 mg/kg/day). (a) Time course of blood glucose levels following glucose challenge (2 g/kg, i.p.). Blood glucose was measured from tail vein immediately before and 30, 60, and 90 minutes following glucose administration. VPA treatment (solid circles) had no effect on glucose tolerance in Wfs1 KO or Wfs1 HZ mice when compared to respective vehicle group (0.9% saline, 10 mL/kg, i.p., open circles). (b) Area under the curve of glucose time curves. Two-way ANOVA followed by Tukey’s HSD test (***𝑃<0.001 versus (+/+SAL); ^§§§𝑃<0.001 versus (+/+VPA); ^$𝑃<0.05 versus (−/−SAL)). Data is presented as mean ± SEM (𝑛=8).

(a)

(b)