Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression Profile in Wfs1 Knockout Mouse

Table 1

List of genes whose expression in mouse liver is regulated by Wfs1 genotype as measured by Affymetrix GeneChip Mouse Gene 1.0 ST Array.

Probeset ID	𝑃 value	𝑄-value	Fold change	Gene	Gene description
Upregulated in Wfs1 KO mice
10362464	6.32𝐸−05	0.028767	131.3	Sult3a1	Sulfotransferase family 3A, member 1
10359593	4.94𝐸−06	0.008869	112.2	Fmo3	Flavin containing monooxygenase 3
10551209	3.81𝐸−04	0.055722	37.6	Cyp2b13	Cytochrome P450, family 2, subfamily b, polypeptide 13
10465726	8.82𝐸−06	0.011336	14.0	BC014805	cDNA sequence BC014805
10561162	7.93𝐸−05	0.031687	10.3	Cyp2a22	Cytochrome P450, family 2, subfamily a, polypeptide 22
10465734	3.50𝐸−06	0.008869	9.8	AB056442	cDNA sequence AB056442
10500570	1.07𝐸−04	0.035569	6.3	Hao2	Hydroxyacid oxidase 2
10506301	1.46𝐸−05	0.013481	5.2	Lepr	Leptin receptor
10425822	7.17𝐸−04	0.080582	5.0	Pnpla3	Patatin-like phospholipase domain containing 3
10520622	5.54𝐸−15	1.79𝐸−10	4.8	Abhd1	Abhydrolase domain containing 1
10468239	4.10𝐸−04	0.05785	4.4	Cyp17a1	Cytochrome P450, family 17, subfamily a, polypeptide 1
10359582	9.44𝐸−07	0.004726	4.4	Fmo2	Flavin containing monooxygenase 2
10397158	1.19𝐸−04	0.037527	3.5	Acot3	acyl-CoA thioesterase 3
10574027	7.39𝐸−04	0.081551	3.5	Mt1	Metallothionein 1
10533401	7.42𝐸−04	0.081551	2.9	Cux2	Cut-like homeobox 2
10350733	3.59𝐸−04	0.053424	2.8	Rgs16	Regulator of G-protein signaling 16
10465740	2.81𝐸−04	0.049115	2.4	Gm6192	Predicted gene 6192
10362472	2.97𝐸−04	0.050271	2.2	Rsph4a	Radial spoke head 4 homolog A (Chlamydomonas)
10467372	6.13𝐸−05	0.028301	2.1	Cyp2c38	Cytochrome P450, family 2, subfamily c, polypeptide 38
10519527	1.29𝐸−04	0.038113	2.1	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A
10529977	3.97𝐸−06	0.008869	2.1	Ppargc1a	Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
10548996	4.56𝐸−04	0.062377	2.0	Slco1a4	Solute carrier organic anion transporter family, member 1a4
10515187	6.50𝐸−04	0.07526	2.0	Cyp4a14	Cytochrome P450, family 4, subfamily a, polypeptide 14
Downregulated in Wfs1 KO mice
10571560	1.68𝐸−04	0.03933	2.0	Mtnr1a	Melatonin receptor 1A
10597875	1.21𝐸−05	0.01261	2.0	Cyp8b1	Cytochrome P450, family 8, subfamily b, polypeptide 1
10454015	1.42𝐸−05	0.01348	2.0	Ttc39c	Tetratricopeptide repeat domain 39C
10502214	5.25𝐸−06	0.00892	2.2	Cyp2u1	Cytochrome P450, family 2, subfamily u, polypeptide 1
10498584	9.12𝐸−06	0.01133	2.4	Rarres1	Retinoic acid receptor responder (tazarotene induced) 1
10482528	2.47𝐸−05	0.01781	2.5	Neb	Nebulin
10579649	4.58𝐸−05	0.02463	2.6	Cib3	Calcium and integrin binding family member 3
10415279	2.82𝐸−05	0.01939	2.6	Fitm1	Fat storage-inducing transmembrane protein 1
10602372	2.33𝐸−06	0.00740	2.6	Alas2	Aminolevulinic acid synthase 2, erythroid
10548931	1.53𝐸−04	0.03829	2.7	Slc15a5	Solute carrier family 15, member 5
10500545	1.25𝐸−04	0.03811	2.8	Hsd3b5	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
10507152	2.10𝐸−04	0.04265	3.0	Cyp4a12b	Cytochrome P450, family 4, subfamily a, polypeptide 12B
10352439	4.13𝐸−06	0.00886	3.1	Susd4	Sushi domain containing 4
10507143	1.99𝐸−04	0.04099	3.1	Cyp4a12a	Cytochrome P450, family 4, subfamily a, polypeptide 12a
10513538	9.25𝐸−05	0.03306	3.1	Mup21	Major urinary protein 21
10545877	4.37𝐸−07	0.00353	3.5	Nat8	N-Acetyltransferase 8 (GCN5-related, putative)
10497381	3.81𝐸−07	0.00353	3.9	Cyp7b1	Cytochrome P450, family 7, subfamily b, polypeptide 1
10545874	5.38𝐸−05	0.02674	4.6	Cml5	Camello-like 5
10463551	1.06𝐸−07	0.00171	6.4	Elovl3	Elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3