Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR<i>γ</i> Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease

<table>Probable MoAs leading from tissue-specific ligand-dependent PPAR<i>γ</i> dysregulation to NAFLD. FSP27/CIDE-C: fat-specific protein 27/cell death-inducing DFF45-like effector; Plin 1, 2, 4: Perilipins 1, 2, and 4; ApoCIV: apolipoprotein C IV; aP2: adipose fatty acid binding protein; FAT/CD36 (or just CD36): fatty acid translocase/cluster determinant 36; FAS: fatty acid synthase; ACC: acetyl-CoA carboxylase; SCD1: stearoyl-CoA desaturase1; MGAT1: monoacylglycerol O-acyltransferase 1; DGAT1: diglyceride acyltransferase 1; DGAT2: diglyceride acyltransferase 2.</table>

PPAR Research

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Figure 3: Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR<i>γ</i> Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease 

Figure 3 | Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease 