Decrease of PPAR𝜹 in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury

Figure 3

Changes in behavioral and pain tests in diabetic rats after STZ induction for two weeks (2W-STZ) or eight weeks (8W-STZ) receiving SCI surgery or sham operation. The 2W-STZ receiving SCI was further treated with/without GSK0660 (0.1 mg/kg) intravenously once daily for 21 days while the 8W-STZ receiving SCI was further treated with/without GW0742 (0.3 mg/kg) intravenously once daily for 14 days. (a) BBB locomotor scale, (b) inclined plane test, (c) limb hanging test, and (d) pain test. Values (mean ± SE) were obtained from each group of six rats. ^∗∗𝑃<0.01 and ^∗∗∗𝑃<0.001 compared with the 2W-STZ group. ^#𝑃<0.05, ^##𝑃<0.01, and ^###𝑃<0.001 compared with the 8W-STZ group. ^§§𝑃<0.01 and ^§§§𝑃<0.001 compared with the 2W-STZ + SCI group.

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