TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation

Figure 3

Dietary capsaicin attenuates cardiac hypertrophy and fibrosis in WT mice on long-term high-salt diet through TRPV1 activation. (a) Photographs of sample hearts from WT and TRPV1^−/− on NS, HS, and HS + Cap group. (b) Heart weight index from various groups (𝑛=7). Mean ± SEM: ^∗𝑃<0.05 versus NS; ^#𝑃<0.05 versus HS. (c) Low-magnification view of hematoxylin and eosin stains of different group histological sections. (d) Masson’s trichrome staining for collage deposition of histological sections from various groups. (e) Quantification of interstitial fibrotic area. Values were expressed as the mean ± SEM from 7 separate experiments. ^∗∗𝑃<0.01 versus NS; ^##𝑃<0.01 versus HS.

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