TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δ Upregulation

Table 1

Cardiac function from WT and TRPV1^−/− mice on ND, HS or HS + Cap diet for 1 year.

Parameter	WT			TRPV1^−/−
	ND	HS	HS + Cap	Nd	HS	HS + Cap
No.	8	8	8	8	8	8
BW, g	27.9 ± 4.2	27.5 ± 3.2	26.9 ± 3.8	30.7 ± 2.0	26.1 ± 2.3	26.2 ± 2.2
LVEDD, 10^−5 m	233 ± 29	287 ± 36**	245 ± 35^#	219 ± 44	280 ± 36^†	288 ± 50^†
LVESD, 10^−5 m	158 ± 27	211 ± 28**	168 ± 22^##	147 ± 32	208 ± 25^††	218 ± 31^††
LVPW, 10^−5 m	79 ± 16	103 ± 16*	75 ± 15^##	72 ± 15	91 ± 12^†	88 ± 9^†
%FS	32 ± 4	26 ± 2**	31 ± 5^#	33 ± 6	26 ± 4^†	24 ± 6^†
LVW/BW (mg/g)	1.93 ± 0.51	3.56 ± 0.90**	2.08 ± 0.85^##	1.58 ± 0.32	2.95 ± 0.63^†	2.93 ± 0.67^†

Data are expressed as the mean ± SEM.
BW, body weight; FS, fractional shortening; LVEDD, LV end-diastolic diameter; LVESD, LV end-systolic diameter; LVPW, LV posterior wall; LVW, LV weight; WT wild-type mice; TRPV1^−/− TRPV1-null mice; NS normal-salt diet; HS high-salt diet; HS + Cap high-salt plus capsaicin diet; *𝑃<0.05  **𝑃<0.01 versus WT-NS; ^#𝑃<0.05  ^##𝑃<0.01 versus WT-HS; ^†𝑃<0.05  ^††𝑃<0.01 versus TRPV1^−/−-NS.