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PPAR Research
Volume 2014 (2014), Article ID 523584, 6 pages
http://dx.doi.org/10.1155/2014/523584
Clinical Study

The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPAR 2 Gene in Patients with Type 1 Diabetes and Nephropathy

1Molecular Medicine, Institute of Translational & Stratified Medicine, Plymouth University Schools of Medicine & Dentistry, John Bull Building, Tamar Science Park, Research Way, Plymouth PL6 8BU, UK
2The Influenza Surveillance Section, Respiratory Diseases Department, Centre for Infectious Disease Surveillance and Control, Public Health England, London NW9 5EQ, UK

Received 22 August 2013; Revised 12 November 2013; Accepted 13 November 2013; Published 22 January 2014

Academic Editor: Ruth Roberts

Copyright © 2014 Bingmei Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the study was to investigate whether a Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (PPARγ2) gene is associated with the progress of diabetic nephropathy in patients with type 1 diabetes. 197 Caucasian patients with type 1 diabetes and ethnically matched 151 normal healthy controls were genotyped for this polymorphism. Results showed that there were no significant differences in the frequencies of the genotypes and alleles of the polymorphism between groups. Multiple regression analysis in 77 patients demonstrated that the rate of decline in renal function in terms of glomerular filtration rate was significantly correlated to the baseline level of cholesterol ( ), mean diastolic blood pressure during follow-up period ( ), and baseline level of HbA1c ( ) adjusting for the effect of diabetes duration and gender, but no significant association was found between the polymorphism and the progression of diabetic nephropathy in our studied population. In summary, our results show that the PPARγ2 polymorphism is unlikely to be associated with the development and progression of the diabetic nephropathy in patients with type 1 diabetes. Further studies in different populations may be warranted to confirm our findings as the sample size in our study was relatively small.