The Rate of Decline of Glomerular Filtration Rate May Not Be Associated with Polymorphism of the PPAR𝜸2 Gene in Patients with Type 1 Diabetes and Nephropathy

Table 2

Genetic data, baseline and follow-up clinical data (means ± SD), and results of comparing these indicators between the PPAR𝛾 genotypes in 77 patients with type 1 diabetes and nephropathy.

Parameters	All patients	PPARγ2 genotype		P value
		Pro12Pro	Pro12Ala
Number (male/female)	77 (34/43)	62 (26/36)	15 (8/7)	0.425
Age (years)	42±13	43±14	38±9	0.206
Diabetes duration (years)	27±9	27±10	25±8	0.519
Change in GFR (mL/min/year)	−3.9±9.3; (−6.7 to 0.9)	−3.6±9.7; (−6.6 to 1.0)	−4.9±8.2; (−7.16 to 0.69)	0.629
Baseline data
HbA1c (mmol/mol)	88.0±6.0	85.8±4.9	95.6±9.3	0.273
Cholesterol (mmol/L)	6.0±1.4	5.9±1.3	6.6±1.5	0.101
Systolic BP (mmHg)	143±25	141±22	151±32	0.181
Diastolic BP (mmHg)	82±13	81±12	84±16	0.465
Mean arterial BP (mmHg)	102±15	101±14	106±19	0.261
Follow-up data
HbA1c (mmol/mol)	78.1±1.6	80.3±0.5	71.6±8.2	0.313
Cholesterol (mmol/L)	5.6±1.5	5.8±1.1	4.9±2.3	0.179
Systolic BP (mmHg)	140±19	140±18	139±21	0.952
Diastolic BP (mmHg)	78±9	79±9	78±10	0.776
Mean arterial BP (mmHg)	99±11	99±11	98±13	0.849

BP: Blood pressure; GFR: glomerular filtration rate; HbA1c: haemoglobin A1c.