Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice

Figure 5

Effects of pioglitazone on cholesterol metabolism and associated hepatic protein expression in KKAy mice. The plasma TC (a), plasma HDL-C (a), plasma LDL-C (c), the levels of liver TC (d), the average food intake (e), gallbladder bile TC (f), and fecal TC (g) were measured as mentioned in Section 2. (h) Representative western blot for ABCA1, ABCG5, ABCG8, LDLR, SR-BI, and β-actin is shown. The lower left bar graph represents statistical data from six individual mice per group. The bands were determined by densitometric analysis and expressed as fold change, after correction for β-actin levels, relative to the control mice. Nor, C57BL/6J mice; Con, vehicle-treated KKAy mice; Piog, pioglitazone-treated KKAy mice. Data are presented as mean ± S.E.M. (𝑛=10 for biochemical analysis and 𝑛=6 for protein analysis). *𝑃<0.05, **𝑃<0.01 versus Con.

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