Peroxisome Proliferator Activator Receptor (PPAR)-<i>γ</i> Ligand, but Not PPAR-<i>α</i>, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver

<table>Effect of fenofibrate (FEN) and pioglitazone (PIO) on hepatic antioxidant enzyme levels in cyclophosphamide (CP)-treated rats. CAT: catalase, SOD: superoxide dismutase, GPX: glutathione peroxidase, GST: glutathione<i> S</i>-transferase. Values are representation of 8 observations as means ± SEM. Results are considered significantly different when <svg height="11.225" id="M6" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 25.637501 11.225" width="25.637501" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.113)"><path d="M619 482q0 -69 -40.5 -119t-96 -72.5t-118.5 -26.5h-44l-70 20l-31 -151q-14 -67 0.5 -83t89.5 -22l-5 -28h-287l8 28q65 7 81.5 22t29.5 83l79 398q12 56 0.5 70.5t-78.5 20.5l7 28h255q108 0 164 -43t56 -125zM524 478q0 141 -146 141q-25 0 -47 -8q-16 -6 -20.5 -13.5
t-10.5 -39.5l-43 -241q37 -13 83 -13q67 0 125.5 45t58.5 129z" id="x1D443"></path></g><g transform="matrix(.017,-0,0,-.017,15.582,11.113)"><path d="M512 -3l-437 233v51l437 233v-58l-378 -200v-2l378 -199v-58z" id="x3C"></path></g>
</svg> 0.05. <sup>a</sup>Significant difference compared to control, <sup>b</sup>significant difference compared to CP group, <sup>c</sup>no significant difference compared to control.</table>

PPAR Research

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Figure 2

Figure 2: Peroxisome Proliferator Activator Receptor (PPAR)-<i>γ</i> Ligand, but Not PPAR-<i>α</i>, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver 

Figure 2 | Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver 