Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver

Table 3

Effect of fenofibrate (FEN) and pioglitazone (PIO) on hepatic tissue reduced glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels in cyclophosphamide (CP)-treated rats.

	GSH (𝜇mol/g tissue)	MDA (nmol/g tissue)	NO (nmol/0.1 g tissue)
Control	28.9 ± 3.8	2.3 ± 0.6	18.3 ± 5.4
FEN	31.1 ± 4.3	1.9 ± 0.6	16.8 ± 2.3
PIO	26.5 ± 4.3	2.4 ± 0.7	21.5 ± 2.5
CP	16.3 ± 3.4^a	7.9 ± 1.8^a	64.2 ± 11.1^a
CP/FEN	18.2 ± 3.2^a	6.8 ± 0.4^a	55.4 ± 12.3^a
CP/PIO	22.8 ± 2.8^b	5.1 ± 0.8^b	27.9 ± 7.4^b,c

Values are representation of 8 observations as means ± SEM. Results are considered significantly different when 𝑃<0.05. ^aSignificant difference compared to control, ^bsignificant difference compared to CP group, ^cno significant difference compared to control.