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PPAR Research
Volume 2014, Article ID 637251, 13 pages
Research Article

PPAR-γ Regulates Trophoblast Differentiation in the BeWo Cell Model

1Research Centre for Women’s and Infants’ Health, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Room 3-904, Toronto, ON, Canada M5G 1Z5
2Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
3Department of Obstetrics and Gynecology, C. S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, MI, USA
4Maternal-Fetal Medicine Division, Department of Obstetrics and Gynecology, Mount Sinai Hospital, 600 University Avenue, Room 3-904, Toronto, ON, Canada M5G 1Z5
5Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada

Received 26 September 2013; Revised 27 December 2013; Accepted 2 January 2014; Published 23 February 2014

Academic Editor: Richard P. Phipps

Copyright © 2014 Khrystyna Levytska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Material contains information which supports or further explains the findings of this manuscript. Included in this report are the Methods table (Supplementary Table 1) and figure (Supplementary Figure 1) outlining antibodies utilized for this study and plasmid design, respectively; as well as the Results supporting figures, specifically: findings supporting our ability of induction of PPAR-γ transcriptional activity via HO-1 as a downstream target (Supplementary Figure 2); the response of primary cytotrophoblast cells to PPAR-γ activity-modulating drugs (Supplementary Figure 3); and the morphological assessment of BeWo cell fusion in response to these treatments (Supplementary Figure 4).

  1. Supplementary Material