Neuroprotective Potential of Peroxisome Proliferator Activated Receptor-α Agonist in Cognitive Impairment in Parkinson’s Disease: Behavioral, Biochemical, and PBPK Profile

Table 1

The input parameters used during the simulation of plasma concentrations versus time profiles of fenofibric acid in rat model.

Sr. number	Input data	Value
1	MW	262.5
2	log𝑃	4.01
3	p𝐾𝑎 (acidic)	3.56
4	Dose	27 mg/kg
5	Lower limit reference solubility (pH 7.4)	0.0294 mg/mL
6	Diffusion coefficient	0.825×10^−5 cm^2/s
7	Particle density	1.2 g/mL
8	Effective particle radius	5 µm
9	Effective permeability	7.66×10^−4 cm/s
10	Physiology	Fasted conditions
11	Absorption model	Opt logD Model SA/V
12	Stomach transit time	0.1 h
13	Body weight	0.25 kg (Rat)
14	Clearance	1.1 mL/min/kg
15	Simulation time	36 h