Role of PPARγ in the Differentiation and Function of Neurons

Figure 1

Overview of PPARs signaling and activation. The figure shows how PPARs are activated. PPARs ligand enters the cell where it binds to promote receptor dimerization with receptor of 9-cis-retinoic acid (RXR). This complex migrates to the nucleus where it binds to DNA and to different cofactors proteins (CBP/p300, SRC1, PBP, and PGC1-α), to induce the expression of several genes involved in metabolism, inflammatory response, and antioxidant defense.