KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation
Expression of KLF15 and PPARα are regulated by physiological and pathological stimuli. (a) Klf15 and Ppara expression in mouse heart during postnatal maturation (). versus day 1. (b) Klf15 and Ppara (top panel) and Nppa/ANF and Nppb/BNP (bottom panel) expression in murine heart tissue in sham (t = 0 weeks) versus transaortic constriction (TAC) at multiple time points (n = 3-4). versus sham. (c) Klf15 and Ppara (top panel) and Nppa/ANF and Nppb/BNP (bottom panel) expression in neonatal rat ventricular cardiomyocytes following exogenous addition of vehicle (t = 0 hours) versus phenylephrine (100 μM) at multiple time points (). versus vehicle. Values normalized to cyclophilin-B (Ppib).