KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation
Ligand induced PPARα gene targets are KLF15 dependent. Fatp1 (a), Pdk4 (b), Slc25a20 (c), Acadm (d), Cpt2 (e), and Cd36 (f) expression (qPCR) in neonatal rat ventricular cardiomyocytes after sh-RNA mediated Klf15 silencing in the absence or presence of the PPARα-specific ligand WY-14,643 (10 μM, 24 hrs). (). versus vehicle. versus sh-KLF15. versus WY-14643. Values normalized to Ppib.
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