Tissue expression | Main tissues: tissues exhibiting high catabolic rates of FA (liver, skeletal muscle) Other tissues: heart, intestine, kidney, and brown adipose tissue | Ubiquitous: however, the biggest expression is in liver, esophagus, intestine, kidney, and skeletal muscle | Main tissue: adipose tissue (white and brown) Other tissues: liver, intestine, kidney, retina, immunologic system (bone marrow, lymphocytes, monocytes, and macrophages), and trace amounts in muscles |
Gene targets | β-oxidation pathway (acyl-CoA oxidation, bifunctional enzyme, and thiolase) Sterol 12-hydroxylase (CYP8B1) FATP FAT/CD36 L-FABP Lipoprotein lipase apo A-I and A-II | Genes involved in lipid uptake; it represses genes implicated in lipid metabolism and efflux | FA-binding protein (aP2) Phosphoenolpyruvate carboxykinase (enzyme of the glyceroneogenesis pathway) FATP FAT/CD36 |