Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?

Figure 2

Main proteins involved in uptake and metabolism of OADs. IR = insulin receptor; GLP-1 = glucagon-like peptide-1; SUR1 = sulphonylureas receptor 1; Kir6.2 = potassium inward rectifier 6.2 subunit; PI3K = phosphoinositide 3-kinase; TCF4 = transcription factor 4; RXR = retinoid X receptor; PI3K/AKT1/GSK3 = phosphoinositide 3-kinase/RAC-alpha serine/threonine-protein kinase/glycogen synthase kinase 3; MAPK = mitogen-activated protein kinases.