Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?

Figure 3

SNPs affecting gene expression and epigenetic mechanism. Schematic representation of how SNPs can potentially affect different processes. (1) A single nucleotide variation (e.g., C to A substitution) may prevent miRNA from binding to its target site in the 3′ untranslated region (UTR) of a gene. (2) SNP may also abrogate the binding site of a transcription factor (TF) and/or the binding of proteins involved in transcription as well as in chromatine remodelling. DNMT = DNA methyltranferase; CH₃ = methyl group.; RNA pol II = RNA polymerase II.