Review Article
Pharmacogenomics of Drug Response in Type 2 Diabetes: Toward the Definition of Tailored Therapies?
Table 1
Schematic catalogue of SNPs commonly associated with T2D.
| Chr | Position | Localization | Gene | Alleles | SNP ID | Protein change | Association |
| 6 | 160543148 160560824 160560881 160575837 | Exon Exon Exon Exon | SLC22A1 | C/T A/G –/A A/C/G | rs12208357 rs34130495 rs35167514 rs34059508 | R61C G401S 420del G465R | Metformin metabolism T2D susceptibility |
| 6 | 160670282 | Exon | SLC22A2 | G/T | rs316019 | S270A | Metformin metabolism T2D development |
| 11 | 17409572 17408630 | Exon Exon | KCNJ11 | T/C G/A | rs5219 rs5215 | K23E A250I | Sulphonylureas metabolism T2D onset |
| 10 | 96702047 96741053 | Exon Exon | CYP2C9 | C/T A/C | rs1799853 rs1057910 | R144C I359L | Sulphonylureas metabolism T2D susceptibility |
| 11 | 17418477 | Exon | ABCC8 | G/T | rs757110 | A1369S | Sulphonylureas metabolism T2D onset |
| 3 | 12393125 | Exon | PPARG | C/G | rs1801282 | P12A | TZD metabolism T2D onset- development |
| 10 | 114808902 114758349 | Intron Intron | TCF7L2 | G/T C/T | rs12255372 rs7903146 | — — | Sulphonylureas metabolism T2D development |
| 2 | 227093745 227660544 | Intergene Exon | IRS1 | C/T G/A | rs2943641 rs1801278 | — G971R | Sulphonylureas treatment T2D onset |
| 2 | 241534293 241531174 241542703 | Intron Intron Intron | CAPN10 | Indel A/G C/T | rs3842570 rs3792267 rs5030952 | — — — | Probably involved in Sulphonylureas response |
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