Smad2/3 Upregulates the Expression of Vimentin and Affects Its Distribution in DBP-Exposed Sertoli Cells

<div>Schematic diagram of the relationship between PPAR<i>α</i> and Smad2/3 in regulation of vimentin in DBP-exposed SCs. DBP stimulated the activity of PPAR<i>α</i>, activated PPAR<i>α</i> promoted the activity of Smad2/3, and activated Smad2/3 upregulated the vimentin mRNA expression. As SB431542 inhibited Smad2/3 and could inhibit PPAR<i>α</i> to some extent, we deduced that Smad2/3 may have a positive feedback response to PPAR<i>α</i>.</div>

PPAR Research

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Figure 5

Figure 5: Smad2/3 Upregulates the Expression of Vimentin and Affects Its Distribution in DBP-Exposed Sertoli Cells 