PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

Figure 4

PPARγ and platelet function. Upon stimulation with PPARγ ligands, platelets decrease expression of multiple proinflammatory proteins and lipids, including PAI-1, CRP, and TxB2. PPARγ ligands also decrease expression of P-selectin and CD40L, thereby decreasing the number of proinflammatory platelet/leukocyte aggregates.