Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention

Table 2

Different effects of TZDs on ENaC.

Nephron segment	Species	Materials	Effects	Citation
Collecting duct	Mouse	Primary cultured IMCD cells	Upregulation of ENaC-γ mRNA expression	[14]
Collecting duct	Mouse	Primary cultured CD cells	Increased Na transport (suppressed in CD PPAR KO)	[15]
CCD	Mouse	Split-opened isolated CCD	Channel activity not altered	[16]
Cortex	Mouse	Kidney cortex lysate	Decrease in ENaC-α and -β subunit mRNA expression; Decrease in ENaC-γ subunit protein expression	[17]
CCD	Mouse	M1 cell line	Decrease in ENaC-α and -γ subunit mRNA expression	[17]
CCD	Mouse	M1 cell line; mpkCCDcl4 cell line	No direct enhancement of Na^+ flux via ENaC	[18]
Kidney	Xenopus laevis	A6 cell line	No direct enhancement of Na^+ flux via ENaC	[18]