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PPAR Research
Volume 2015, Article ID 785783, 12 pages
http://dx.doi.org/10.1155/2015/785783
Research Article

AICAR Protects against High Palmitate/High Insulin-Induced Intramyocellular Lipid Accumulation and Insulin Resistance in HL-1 Cardiac Cells by Inducing PPAR-Target Gene Expression

1Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, Netherlands
2Department of Pharmacology and Therapeutic Chemistry, Biomedicine Institute of University of Barcelona (IBUB), Pediatric Research Institute-Sant Joan de Déu Hospital and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Faculty of Pharmacy, University of Barcelona, Diagonal 643, 08028 Barcelona, Spain
3Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, “Sant Joan” University Hospital, Pere Virgili Health Research Institute (IISPV) and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Faculty of Medicine and Health Sciences, Rovira i Virgili University, Sant Llorenç 21, 4301 Reus, Spain

Received 30 July 2015; Revised 26 October 2015; Accepted 27 October 2015

Academic Editor: Shinichi Oka

Copyright © 2015 Ricardo Rodríguez-Calvo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

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  • Ho-Shan Niu, Chin-Hong Chang, Chiang-Shan Niu, Juei-Tang Cheng, and Kung-Shing Lee, “Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats,” Drug Design Development And Therapy, vol. 10, pp. 1877–1884, 2016. View at Publisher · View at Google Scholar
  • Ricardo Rodríguez-Calvo, Dipanjan Chanda, Yvonne Oligschlaeger, Marie Miglianico, Will A Coumans, Emma Barroso, Marta Tajes, Joost JFP Luiken, Jan FC Glatz, Manuel Vázquez-Carrera, and Dietbert Neumann, “Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes,” Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017. View at Publisher · View at Google Scholar
  • Jing Nie, Debra C DuBois, Bai Xue, William J Jusko, and Richard R Almon, “Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats,” Gene Regulation and Systems Biology, vol. 11, pp. 117762501771000, 2017. View at Publisher · View at Google Scholar
  • Romina Hermann, Victoria Evangelina Mestre Cordero, María de las Mercedes Fernández Pazos, Federico Joaquín Reznik, Débora Elisabet Vélez, Enrique Alberto Savino, María Gabriela Marina Prendes, and Alicia Varela, “Differential effects of AMP-activated protein kinase in isolated rat atria subjected to simulated ischemia–reperfusion depending on the energetic substrates available,” Pflügers Archiv - European Journal of Physiology, 2017. View at Publisher · View at Google Scholar
  • Yun Zhao, Lu Yan, Lu Peng, XueFeng Huang, GuiXiang Zhang, BingqQian Chen, Jie Ren, Yu Zhou, LiChao Yang, Li Peng, Xin Jin, and YiQing Wang, “Oleoylethanolamide alleviates macrophage formation via AMPK/PPARα/STAT3 pathway,” Pharmacological Reports, 2018. View at Publisher · View at Google Scholar
  • Petr Jezek, Blanka Holendová, Keith D. Garlid, and Martin Jaburek, “Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling,” Antioxidants & Redox Signaling, 2018. View at Publisher · View at Google Scholar