Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

Figure 2

Interaction mode of full agonist rosiglitazone. The PPARγ ligand binding domain is shown in yellow and rosiglitazone is shown in white sticks coloured by element. (a) Ribbons diagram of the PPARγ ligand binding domain bound to rosiglitazone. The branches of the ligand binding pocket have been labelled with Roman numerals. (b) Hydrogen bond network of the rosiglitazone TZD head group with AF2 residues. PDB: 4EMA [49].

(a)

(b)