Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Table 3
Ultrasonographic markers of carotid atherosclerosis due to rs1801282 genotypes in patients with T2DM at the time of recruitment.
Pro12AlaPPAR
CC
GC + GG
CIMT (μm)
1006 ± 210
1026 ± 209
0.39
Number of sites with plaque
2.56 ± 1.57
2.36 ± 1.82
0.31
Total plaque thickness (mm)
7.98 ± 4.47
7.65 ± 4.64
0.58
Presence of plaques
+
365 (86.5)
133 (76.9)
0.005
−
57 (13.5)
40 (23.1)
Presence of unstable plaques
+
213 (58.4)
74 (55.6)
0.61
−
152 (41.6)
59 (44.4)
Coronary calcium score
250 ± 315
269 ± 367
0.1
Number of coronary arteries with more than 50% stenosis
0.7 ± 0.9
0.9 ± 1.2
0.4
The presence of at least 1 vessel with more than 50% stenosis
24 (38.9%)
63 (41.1%)
0.2
Coronary computed tomography angiography (CCTA) was performed for diagnostic purposes in 215 out of 595 subjects with T2DM.