IL-15 Mediates Mitochondrial Activity through a PPARδ-Dependent-PPARα-Independent Mechanism in Skeletal Muscle Cells

Figure 3

Effects of IL-15 signaling on mitochondrial biogenesis. (a) mitochondrial DNA (mtDNA) assessments; (b) mRNA expression of mitochondrial factor Tfam. Assessments were carried out on differentiated C2C12 myotubes following treatment with 100 ng/mL of IL-15 every other day for 6 days during the differentiation protocol. mtDNA was normalized to the total nuclearDNA (nucDNA) content. GAPDH was used as an internal control for qPCR analysis. All values are displayed as means ± SEM, .

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