Research Article
HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy
Figure 5
Cardiac peroxisome proliferator-activated receptor (PPAR) proteins in control, diabetes mellitus (DM), and MPT0E014-treated DM (DM + MPT0E014) rats. Cardiac PPAR-α and PPAR-δ protein expressions significantly decreased in DM () compared to control () and DM + MPT0E014 () rats. Cardiac PPAR-γ protein expressions were enhanced in DM () compared to control () and DM + MPT0E014 () rats. Representative immunoblots and average data of (a) PPAR-α, (b) PPAR-γ, and (c) PPAR-δ in different groups. Densitometry was normalized to glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as an internal control.
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