Clinical Study

PPARα Agonist Fenofibrate Reduced the Secreting Load of β-Cells in Hypertriglyceridemia Patients with Normal Glucose Tolerance

Table 1

Baseline characteristics of the NTG and HTG groups.

ParametersNTG group ()HTG group ()

Age, y40.89 ± 11.9942.37 ± 10.38
Gender, males/females632/670374/298
WC, cm89.12 ± 5.4293.68 ± 6.62
BMI, kg/m223.32 ± 4.4026.14 ± 3.85
TC, mmol/L4.77 ± 0.855.25 ± 0.90
LDL-C, mmol/L2.79 ± 0.722.96 ± 0.74
HDL-C, mmol/L1.34 ± 0.301.06 ± 0.21
TG, mmol/L0.95 (0.71–1.26)2.24 (1.95–2.88)
FBG, mmol/L5.33 ± 0.385.47 ± 0.34
FINS, mIU/L9.80 (6.77–13.79)16.17 (11.25–21.93)
HOMA-IR2.30 (1.56–3.29)3.86 (2.76–5.42)
HOMA-110.30 (77.02–154.92)164.15 (114.05–228.80)

Data are means ± SD unless indicated otherwise. TG, FINS, HOMA-IR, and HOMA- are shown as medians and upper and lower quartiles. WC: waist circumference; BMI: body mass index; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; TG: triglyceride; FBG: fasting blood glucose; FINS: fasting insulin; HOMA-IR: homeostasis model assessment of insulin resistance; HOMA-β: homeostasis model assessment of β-cell function. Significantly different at versus control; significantly different at versus control.