Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?

Figure 4

Representative images of GSC morphology after treatment with increasing concentrations of Pio for 24, 48, and 72 hs. Generally, Pio did not induce any relevant morphological change. Images of G144 cells show that GSCs still grow as neurospheres in nonadherent conditions after drug exposure. Black arrows indicate insoluble threadlike precipitates, which can also be observed on the cell surfaces.