Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?

Table 1

Expression of stemness and differentiation markers in GSC lines in response to Pio treatment.

GSC lines	Treatment	CD133	Nestin	βIII tubulin	GFAP	MBP
		%	%	%	%	%
GBM2	Untreated	62,96	75,44	19,27	63,81	100
	Pio 10 μM 72 hs	50	0	0	0	0
GBM04	Untreated	86,29	96,58	76,78	86,08	0
	Pio 10 μM 72 hs	100	100	100	100	100
G144	Untreated	78,38	91,35	45,79	82,46	100
	Pio 10 μM 72 hs	100	100	100	100	0
G166	Untreated	7,34	78,3	25,92	83,9	100
	Pio 10 μM 72 hs	0	100	100	100	0
G179	Untreated	100	99,17	100	98,21	0
	Pio 10 μM 72 hs	100	100	100	100	100
GliNS2	Untreated	100	79,63	71,43	93,64	100
	Pio 10 μM 72 hs	100	0	0	16,2	0

Fisher’s exact test on raw data: < 0,05; < 0,001.