PPAR Research

Research Article

Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?

Table 2

Fold regulation and trend of the expression variations of 7 Wnt pathway-focused genes in response to Pio treatment.
 G179GBM2G166G144GliNS2GBM04
 F.R.TrendF.R.TrendF.R.TrendF.R.TrendF.R.TrendF.R.Trend
WNT1−3,490↓8,273↑1,015=−2,311↓1,169=−1,266=
FZD41,159=1,213=−1,120=1,087=−1,017=1,151=
CTNNB1−1,071=1,025=−1,288=1,471=−1,117=1,022=
TCF7−1,249=1,683↑−1,147=−1,369=1,047=−1,003=
MYC−1,052=3,216↑1,452=−1,058=1,065=−1,040=
EP3001,561↑−1,228=1,097=1,091=−1,058=−1,077=
CREBBP1,539↑−1,497=1,172=1,219=−1,050=1,101=
Gene expression levels in GSCs were evaluated by means of RT-PCR after Pio 10 μM exposure for 96 hs. F.R.: fold regulation; ↑: upregulated; ↓: downregulated; =: unchanged.