Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator-Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy

Figure 6

Impaired cardiac function upon vascular-specific PPARβ/δ overexpression, which worsens after myocardial infarction. (a) Echocardiographic examination indicates increased systolic and diastolic volumes, a reduced fractional shortening, and a decreased ejection fraction in animals with vessel-specific overexpression of PPARβ/δ, which becomes more evident after myocardial infarction (b) (Tie2-CreERT2;PPARβ/δ + Tamoxifen, , and Tie2-CreERT2;PPARβ/δ + vehicle, ). IVS: interventricular septum; LVID: left ventricular internal diameter; LVPW: left ventricular posterior wall. Data are means ± SEM. , , and .

(a)

(b)