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PPAR Research
Volume 2017, Article ID 1924907, 7 pages
https://doi.org/10.1155/2017/1924907
Clinical Study

Myocardial Expression of PPARγ and Exercise Capacity in Patients after Coronary Artery Bypass Surgery

1Institute of Cardiology, Intensive Cardiac Therapy Clinic, Alpejska St. 42, 04-628 Warsaw, Poland
2Department of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza St. 2c, 15-222 Bialystok, Poland
3Institute of Cardiology, Department of Cardiac Rehabilitation and Noninvasive Electrocardiology, Alpejska St. 42, 04-628 Warsaw, Poland
4Institute of Oncology, Department of Molecular and Translational Oncology, Wawelska St. 15B, 02-034 Warsaw, Poland

Correspondence should be addressed to Izabela Wojtkowska; lp.po@tjowalebazi

Received 30 May 2017; Revised 21 July 2017; Accepted 21 August 2017; Published 28 September 2017

Academic Editor: Qinglin Yang

Copyright © 2017 Izabela Wojtkowska et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Activation of PPARs may be involved in the development of heart failure (HF). We evaluated the relationship between expression of PPAR in the myocardium during coronary artery bypass grafting (CABG) and exercise tolerance initially and during follow-up. 6-minute walking test was performed before CABG, after 1, 12, 24 months. Patients were divided into two groups (HF and non-HF) based on left ventricular ejection fraction and plasma proBNP level. After CABG, 67% of patients developed HF. The mean distance 1 month after CABG in HF was  m versus  m in non-HF. PPAR mRNA expression was similar in both HF and non-HF groups. 6MWT distance 1 month after CABG was inversely correlated with PPAR level only in HF group. Higher PPAR expression was related to smaller LVEF change between 1 month and 1 year (, ), especially in patients with HF. Higher initial levels of IL-6 in HF patients were correlated with longer distance in 6MWT one month after surgery and lower PPAR expression. PPAR expression is not related to LVEF before CABG and higher PPAR expression in the myocardium of patients who are developing HF following CABG may have some protecting effect.