MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers

Figure 1

Human miRNAs targeting PPAR isoforms and involved in metabolic diseases and cancer. MetaCore pathway analysis software from Thomson Reuters was used to identify experimentally the number of validated human miRNAs involved in cancer (grey circle). Among those, the numbers of miRNAs involved in metabolic diseases, also identified by MetaCore pathway analysis, are indicated in blue circles. In red circles are the number of miRNAs identified using miRWalk 2.0 atlas and targeting PPARα (Panel (a)), PPARβ/δ (Panel (b)), and PPARγ (Panel (c)). The identities of miRNAs targeting specific PPAR isoforms and involved in both cancer and metabolic diseases are indicated in violet. miRWalk 2.0 atlas is a software integrating 12 different prediction algorithms (miRWalk 2.0, MicroT4, miRanda, miRBridge, miRDB, miRMap, miRNAMap, PICTAR2, PITA, RNA22, RNAhybrid, and TargetScan) for identification of miRNAs target mRNAs.

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