MicroRNAs-Dependent Regulation of PPARs in Metabolic Diseases and Cancers

Table 2

PPARα- and PPAR-dependent miRNAs induction in specific tissues and pathophysiological processes.

(a) PPARα

miRNA	Biological process	Organism	Cell/tissue	Reference
Let-7	Proliferation	Mouse	Liver tissue,; HCC cell line	Shah et al., 2007 [71]
miR-200c	Migration	Human	HCC cell line	Zhang et al., 2011 [132]

(b) PPARγ

miRNA	Biological process	Organism	Cell/tissue	Reference
miR-98	Endothelial dysfunction; Pulmonary hypertension	Mouse; Human	Primary pulmonary artery endothelial cells	Kang et al., 2016 [103]
miR-125b	Proliferation; Apoptosis	Human	Ovarian cancer tissue,; Ovarian cancer cell lines	Luo et al., 2015 [130]
miR-145	Inflammation; Oxidative stress	Rat	Cerebral cortex,; Pheochromocytoma cell line	Dharap et al., 2015 [17]
	Collagen synthesis	Human	Hypertrophic scar fibroblasts	Zhu et al., 2015 [131]
	Cell cycle; Invasion; Differentiation	Human	Colorectal cancer tissue and colorectal cancer cell lines	Panza et al., 2014 [96]
miR-223	Inflammation	Mouse	Bone marrow derived macrophages; Adipocyte-derived stromal cells; Primary adipocytes	Ying et al., 2015 [133]
miR-329	Inflammation; Oxidative stress	Rat	Cerebral cortex,; Pheochromocytoma cell line	Dharap et al., 2015 [17]
miR-339-5p	Adipocyte differentiation	Human	White adipose tissue; Isolated preadipocytes	Yu et al. 2014 [134]
miR-378	Adipocyte differentiation	Human	White adipose tissue; Primary adipose derived stromal cells	Yu et al., 2014 [134]