Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions

Figure 4

Levels of total cholesterol, high-density lipoprotein cholesterol (HDL cholesterol), low-density lipoprotein cholesterol (LDL cholesterol), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) in serum of WKY rats and SHRs given high-fat diet and fimasartan. The concentrations of total cholesterol, HDL cholesterol, LDL cholesterol, GOT, and GPT in serum were estimated with TOSHIBA TBA-2000FR according to manufacturer’s instructions. The results are expressed as means ± SEM (). Values were statistically analyzed by unpaired t-test or one-way ANOVA. All experiments were repeated three times. Meaning of indications: WKY means normal control rat given normal diet containing 10% fat, S10 means SHRs given normal diet containing 10% fat, S10F means SHRs given normal diet containing 10% fat plus fimasartan, S60 means SHRs given high-fat diet containing 60% fat, and S60F means SHRs given high-fat diet containing 60% fat plus fimasartan.

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