Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway

Figure 3

Molecular mechanism governing ANGPTL4-mediated TG hydrolysis. LPL monomer is linked to nANGPTL4 protein fraction, thus shifting the balance between LPL dimers and monomers towards the latter. As a consequence, LPL is inhibited and this causes the alteration of TG clearance from the plasma and uptake decrease of FFA into the peripheral tissues. The intervention of ANGPTL4 on LPL causes also the reduction of LPL affinity for GPIHBP1 protein.