Potential Role of ANGPTL4 in the Cross Talk between Metabolism and Cancer through PPAR Signaling Pathway

Figure 6

Potential cross talk between lipid/glucidic metabolism and cancer. Molecular pathways involved in communication between lipid/glucidic metabolism and cancer highlighting the key roles of PPAR and ANGPTL4. Abbreviations: ANGPTL3, angiopoietin-like 3; ANGPTL4, angiopoietin-like 4; Cox-2, cyclooxygenase-2; ERK, extracellular signal-regulated kinases; FFA, free fatty acids; HIF-1α, hypoxia-inducible factor-1 alpha; IGF-1, insulin-like growth factor-1; IL-1β, interleukin-1 beta; IL-6, interleukin-6; IL-8, interleukin-8; LDL, low-density lipoprotein; LPL, lipoprotein lipase; MAPK, mitogen-activated protein kinase; PAI-1, plasminogen activator inhibitor-1; PGE2, prostaglandin E2; PKBα, protein kinase B alpha; PPARs, peroxisome proliferator-activated receptors; ROS, reactive oxygen species; Src, V-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene; TG, triglycerides; TNF-α, tumor necrosis factor-alpha.