Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Figure 1

Classification of new-generation insulin sensitizers based on their mechanisms or targets. AMPK, adenosine monophosphate-activated protein kinase; CQ, chloroquine; FGF, fibroblast growth factor; HCQ, hydroxychloroquine; 11β-HSD1, 11β-hydroxysteroid dehydrogenase type 1; HSP, heat shock protein; mTOT, mitochondrial target of TZDs; mitoNEET, mitochondrial Asn-Glu-Glu-Thr; NOS, nitric oxide synthase; PKA, protein kinase A; PPARγ, peroxisome proliferator-activated receptor γ; TZDs, thiazolidinediones.