Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets

Figure 2

Schematic representation of the mechanism of PPARγ agonist signaling. L, ligand (including natural ligand and synthetic PPARγ agonist); CoRep, corepressor; CoAct, coactivator; FABP, fatty acid-binding protein; PPAR, peroxisome proliferator-activated receptor; RXR, retinoid X receptor; PPRE, PPARγ response elements.