Crosstalk between the Androgen Receptor and PPAR Gamma Signaling Pathways in the Prostate

Figure 2

AR regulates PPAR signaling in human prostate cancers. Data from our laboratory suggest that androgen-induced AR activation produces a net decrease in PPAR protein and PPAR activity in AR-positive castration-sensitive (VCaP) and castration-resistant (C4-2) prostate cancer cells. These decreases in PPAR transcriptional activity result in reduced expression of FABP4 and other PPAR target genes and ultimately alterations in cancer cell proliferation and metabolism that promote tumor growth.